Rodent models for dystonia research: Characteristics, evaluation, and utility
Identifieur interne : 003743 ( Main/Exploration ); précédent : 003742; suivant : 003744Rodent models for dystonia research: Characteristics, evaluation, and utility
Auteurs : H. A. Jinnah [États-Unis] ; Ellen J. Hess [États-Unis] ; Mark S. Ledoux [États-Unis] ; Nutan Sharma [États-Unis] ; Mark G. Baxter [Royaume-Uni] ; Mahlon R. Delong [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-03.
English descriptors
- KwdEn :
- Animals, Disease Models, Animal, Dystonia (drug therapy), Dystonia (genetics), Dystonia (physiopathology), Evaluation Studies as Topic, Gene Expression (genetics), Gene Library, Mice, Mice, Knockout, Mice, Transgenic, Muscle, Skeletal (physiopathology), Neurodegenerative Diseases (genetics), Phenotype, animal models, dystonia, knockout mice, pathogenesis, transgenic mice.
- MESH :
- drug therapy : Dystonia.
- genetics : Dystonia, Gene Expression, Neurodegenerative Diseases.
- physiopathology : Dystonia, Muscle, Skeletal.
- Animals, Disease Models, Animal, Evaluation Studies as Topic, Gene Library, Mice, Mice, Knockout, Mice, Transgenic, Phenotype.
Abstract
A large number of different genetic and acquired disorders of the nervous system may be associated with dystonia. To elucidate its pathogenesis and to facilitate the discovery of potential novel treatments, there has been a growing interest in the development of animal models and particularly rodent models. Multiple animal models for dystonia have now been developed and partially characterized. The results obtained from studies of these models often lead in very different directions, in part because the different models target different aspects of a very heterogeneous disorder. A recent workshop addressed four main issues affecting those who conduct dystonia research with animal models, including the different ways in which dystonic disorders can be modeled in rodents, key features that constitute a useful model, methods used in the evaluation of these models, and recommendations for future research. This review summarizes the main outcomes of this conference. © 2005 Movement Disorder Society
Url:
DOI: 10.1002/mds.20364
Affiliations:
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Ledoux</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Tennessee Health Science Center, Memphis, Tennessee</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Sharma, Nutan" sort="Sharma, Nutan" uniqKey="Sharma N" first="Nutan" last="Sharma">Nutan Sharma</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Harvard Medical School, Boston Massachusetts</wicri:regionArea><wicri:noRegion>Boston Massachusetts</wicri:noRegion></affiliation></author><author><name sortKey="Baxter, Mark G" sort="Baxter, Mark G" uniqKey="Baxter M" first="Mark G." last="Baxter">Mark G. Baxter</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Experimental Psychology, Oxford University, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Delong, Mahlon R" sort="Delong, Mahlon R" uniqKey="Delong M" first="Mahlon R." last="Delong">Mahlon R. Delong</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Emory University, Atlanta Georgia</wicri:regionArea><wicri:noRegion>Atlanta Georgia</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-03">2005-03</date><biblScope unit="vol">20</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="283">283</biblScope><biblScope unit="page" to="292">292</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">B8C763CD6EBAF44EB5E27BA36EDE5BBDE4248D8D</idno><idno type="DOI">10.1002/mds.20364</idno><idno type="ArticleID">MDS20364</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Dystonia (drug therapy)</term><term>Dystonia (genetics)</term><term>Dystonia (physiopathology)</term><term>Evaluation Studies as Topic</term><term>Gene Expression (genetics)</term><term>Gene Library</term><term>Mice</term><term>Mice, Knockout</term><term>Mice, Transgenic</term><term>Muscle, Skeletal (physiopathology)</term><term>Neurodegenerative Diseases (genetics)</term><term>Phenotype</term><term>animal models</term><term>dystonia</term><term>knockout mice</term><term>pathogenesis</term><term>transgenic mice</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dystonia</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Dystonia</term><term>Gene Expression</term><term>Neurodegenerative Diseases</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dystonia</term><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Evaluation Studies as Topic</term><term>Gene Library</term><term>Mice</term><term>Mice, Knockout</term><term>Mice, Transgenic</term><term>Phenotype</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A large number of different genetic and acquired disorders of the nervous system may be associated with dystonia. To elucidate its pathogenesis and to facilitate the discovery of potential novel treatments, there has been a growing interest in the development of animal models and particularly rodent models. Multiple animal models for dystonia have now been developed and partially characterized. The results obtained from studies of these models often lead in very different directions, in part because the different models target different aspects of a very heterogeneous disorder. A recent workshop addressed four main issues affecting those who conduct dystonia research with animal models, including the different ways in which dystonic disorders can be modeled in rodents, key features that constitute a useful model, methods used in the evaluation of these models, and recommendations for future research. This review summarizes the main outcomes of this conference. © 2005 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Maryland</li><li>Oxfordshire</li><li>Tennessee</li></region><settlement><li>Oxford</li></settlement></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Jinnah, H A" sort="Jinnah, H A" uniqKey="Jinnah H" first="H. A." last="Jinnah">H. A. Jinnah</name></region><name sortKey="Delong, Mahlon R" sort="Delong, Mahlon R" uniqKey="Delong M" first="Mahlon R." last="Delong">Mahlon R. Delong</name><name sortKey="Hess, Ellen J" sort="Hess, Ellen J" uniqKey="Hess E" first="Ellen J." last="Hess">Ellen J. Hess</name><name sortKey="Ledoux, Mark S" sort="Ledoux, Mark S" uniqKey="Ledoux M" first="Mark S." last="Ledoux">Mark S. Ledoux</name><name sortKey="Sharma, Nutan" sort="Sharma, Nutan" uniqKey="Sharma N" first="Nutan" last="Sharma">Nutan Sharma</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Baxter, Mark G" sort="Baxter, Mark G" uniqKey="Baxter M" first="Mark G." last="Baxter">Mark G. Baxter</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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